Diuretics

Diuretics are medicines that can increase the speed of formation of urine. Diuresis term has two senses, first demonstrated the addition of the volume of urine produced and the second indicates the amount of expenditure of solutes in water.

The main function of diuretics is to mobilize edema fluid, which means changing the balance of fluid in such a way that the extracellular fluid volume returned to normal.

Diuretics can be divided into five groups, namely:
1. Osmotic diuretic
2. Class of enzyme inhibitor diuretics carbonic anhydrase
3. Thiazide diuretic class
4. Potassium-sparing diuretics
5. Powerful diuretic

    1. Osmotic diuretic
       Osmotic diuretics have their place of work:

1. Tubuli proximal.Osmotic diuretic is working on the proximal tubuli by inhibiting reabsorption of sodium and water through the power osmotiknya.  
2. Ansa enle .Osmotic diuretic is working on Ansa Henle by inhibiting the reabsorption of sodium and water thus decreasing hipertonisitas medulla region.  
3. Collecting ducts  .Osmotic diuretic is working on collecting ducts by inhibiting reabsorption of sodium and water due to papillary wash out, a high filtrate flow rate, or the presence of other factors.  The term usually dipakaiuntuk osmotic diuretic substance is not an easy and rapid electrolyte excreted oeh kidney. Examples of osmotic diuretics are: mannitol, urea, glycerin and isisorbid.

   2. Class of enzyme inhibitor diuretics carbonic anhydrase
      Diuretics are working on Proximal tubuli by inhibiting the reabsorption of bicarbonate.
      Which included diuretics are asetazolamid, diklorofenamid and meatzolamid.
   3. Thiazide diuretic class
      Thiazide diuretic group is working on the upstream distal tubuli by inhibiting reabsorption of sodium chloride. Drugs of this class of diuretics that termsuk is; klorotiazid, hydrochlorothiazide, hidroflumetiazid, bendroflumetiazid, politiazid, benztiazid, siklotiazid, metiklotiazid, klortalidon, kuinetazon, and indapamid.
   4. Potassium-sparing diuretics
      Potassium-sparing diuretics are working on a downstream distal tubuli and collecting ducts cortical areas by inhibiting the reabsorption of sodium and potassium secretion by competitive antagonism (sipironolakton) or directly (triamteren and amilorida).
   5. Powerful diuretic
      These powerful diuretics work on Ansa Henle ascending section in sections with a thick epithelium by inhibiting the transport of electrolytes sodium, potassium, and chloride.
      Which includes a strong diuretic is; etakrinat acid, furosemide and bumetamid.
Clinical use of diuretics

1. Hypertension Thiazide diuretic group, step 1 is the main option, in most patients.  Strong diuretic (usually furosemide), used when there is impaired renal function or when required diuretic effect immediately. Potassium-sparing diuretics, used together with thiazide diuretics, or strong, if there is danger of hypokalemia.
2. Chronic congestive heart pains  Thiazide diuretic group, digunakann when normal renal function. Powerful diuretic furosemide often, especially useful in patients with impaired function ginja. Potassium-sparing diuretics, used together with thiazide diuretics are strong or when there is danger of hypokalemia. 
3. Acute pulmonary edema Typically use strong diuretics (furosemide) 
4. Nephrotic syndrome Or thiazide diuretics are usually used together with spironolactone strong.
5. Acute kidney pains Mannitol and / or furosemide, when diuresis is successful, the volume of lost body fluids should be replaced with caution.
6. Chronic liver disease spironolactone (alone or with thiazide diuretics, or strong).
7. Brain edema Osmotic diuretic 
8. Hiperklasemia Diuretic furosemide, administered with intravenous NaCl hipertonis
9. Kidney stones Thiazide diuretics 
10. Diabetes insipidus Thiazide diuretic group is accompanied by a low-salt diet
11. Open angle glaucoma  Diuretics are used for long-term asetazolamid.  
12. Acute angle closure glaucoma Osmotic diuretics or asetazolamid used prabedah. For the selection of a proper Diuretic drugs it's good you have to consult and consult a doctor.

In the online pharmacies you can search medicastore diuretic drug with a different brand with the same content simply by typing in the search engines medicastore. So you can choose and buy diuretics to suit your needs.

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